Indolinyl-sulfonamide inhibitors of tankyrase and methods of use thereof

US10420758B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Lawrence G. Lum · Charlottesville, US
• Chuo Chen · Dallas, US
• Xuewu Zhang · Beijing, CN
• Ozlem Kulak · Dallas, US
• Xiaofeng Wu · Neubiberg, DE

Key dates

• Filing date: May 2, 2016
• Grant date: Sep 24, 2019
• Expiry date: May 2, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K45/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides compounds that may be useful for inhibiting the Tankyrase enzyme. In some aspects, these compounds are useful in the treatment of a disease or disorder related to the misregulation of Tankyrase enzyme such as cancer, degenerative diseases, or fibrotic diseases. Also provided herein are compounds may also be used to prevent the elongation of the telomere in a cell.