Patent · US Active

Pyrrolobenzodiazepines and conjugates thereof

US10420777B2 · kind B2 · utility

1Cited by

59References

19Claims

0Family size

Inventors

Philip Wilson Howard · London, GB
Stephen John Gregson · London, GB
Jean-Noel Levy · South San Francisco, US

Key dates

Filing date	Sep 11, 2015
Grant date	Sep 24, 2019
Priority date	—
Expiry date	Oct 12, 2035

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A conjugate comprising a PBD dimer linked from the tether joining the two PBD units, wherein the linker is of formula (A1):(Formula (A1)) wherein RN1 is selected from H and C1-4 alkyl; L is a linker connected to a cell binding agent; CBA is the cell binding agent; n is an integer selected in the range of 0 to 48; Q is: (Formula (Q)), where Qx is such that Q is an amino-acid residue, a dipeptide residue or a tripeptide residue.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.