Pleuromutilin derivative having 2-amino phenyl mercaptan side chain as well as preparation method and application thereof
US10421715B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 29, 2018 |
| Grant date | Sep 24, 2019 |
| Priority date | — |
| Expiry date | Dec 29, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/82
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A pleuromutilin derivative having a 2-amino phenyl mercaptan side chain as well as a preparation method and application thereof are provided. The derivative has a structure represented by formula 2 or formula 3, wherein, R1, R2 and R3 are each independently selected from a hydrogen atom, hydroxyl, amino, sulfydryl, hydroxymethyl, amine methyl, nitro, halogen, trihalogenated methyl, methyl, natural amino acid acylamino and C1-6 alkoxy. The plueuromutilin derivative in the disclosure has good activity of inhibiting drug-resistant Staphylococcus aureus and mycoplasma, and is especially suitable for preventing and treating infectious diseases caused by human or animal mycoplasma or drug-resistant Staphylococcus aureus or multidrug resistant bacteria as a novel antibacterial drug.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.