Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase

US10421756B2 · kind B2 · utility

Assignee

• Rodin Therapeutics, Inc. · US

Inventors

• Martin R. Jefson · Stonington, US
• John A. Lowe, III · Stonington, US
• Fabian Dey · Basel, CH
• Andreas Bergmann · Berlin, DE
• Andreas Schoop · Overath, DE

Key dates

• Filing date: Jul 5, 2016
• Grant date: Sep 24, 2019
• Expiry date: Jul 5, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula (I) or any one of Compounds 100-175) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.