Factor VIII compositions and methods of making and using same

US10421798B2 · kind B2 · utility

Assignee

• BIOVERATIV THERAPEUTICS INC. · US

Inventors

• Volker Schellenberger · Palo Alto, US
• Pei-Yun Chang · Menlo Park, US
• Fatbardha Varfaj · Mountain View, US
• Sheng Ding · Changzhou City, CN
• Joshua Silverman · Los Altos Hills, US
• Chia-Wei Wang · Santa Clara, US
• Benjamin Spink · San Carlos, US
• Willem P. Stemmer · Los Gatos, US
• Nathan Geething · Santa Clara, US
• John KULMAN · Belmont, US
• Tongyao Liu · Lexington, US
• Garabet G. Toby · North Reading, US
• Haiyan Jiang · Belmont, US
• Robert T. Peters · Needham, US
• Deping Wang · Furlong, US
• Baisong Mei · Newton, US

Key dates

• Filing date: Jul 11, 2012
• Grant date: Sep 24, 2019
• Expiry date: May 23, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/31
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.