Preparation method of new-type nanoparticles for loading emodin

US10421852B2 · kind B2 · utility

Assignee

• Guangdong Provincial Hospital of TCM · CN

Inventors

• Xusheng Liu · 流花街道, CN
• Qizhan Lin · 流花街道, CN
• Chuan Zou · 流花街道, CN
• Fuhua Lu · 流花街道, CN
• Zhaoyu LU · 流花街道, CN
• Xiuqing Wu · 流花街道, CN
• Yuchi Wu · 流花街道, CN
• Chunlan Ji · 流花街道, CN

Key dates

• Filing date: Nov 16, 2017
• Grant date: Sep 24, 2019
• Expiry date: Mar 31, 2038

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R33/46
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a preparation method of new-type nanoparticles for loading emodin, which comprises: using L.A, mPEG and stannous iso caprylate to synthesize a first intermediate product; using the first intermediate product, butanedioic anhydride and 4-dimethylaminopyridine to synthesize a second intermediate product; using the second intermediate product, 1-ethyl-(3-dimethylamino propyl) carbodiimide hydrochloride, N-hydroxysuccinimide and chitosan to synthesize a third intermediate product; using the third intermediate product and sodium periodate to synthesize a fourth intermediate product; using the fourth intermediate product and 5-amino-2-mercapto benzimidazole to synthesize the new-type thiolated nanoparticles. The nanoparticles loaded with emodin are used for intestinal tract dose, which may enhance the nanoparticles' adhesion ability, prolong residence time of drugs on mucosal membranes, and facilitate sustained-release of drug molecules. The encapsulation efficiency after loading drugs is no less than 83.6%, the drug loading capacity is no less than 3.89%, and good water solubility and biological degradability are provided.