Diffusion layer for an enzymatic in vivo sensor

US10422765B2 · kind B2 · utility

Assignee

• Roche Diabetes Care, Inc. · US

Inventors

• Arnulf Staib · Heppenheim, DE
• Marcel Thiele · Rheda-Wiedenbrück, DE
• Karl-Heinz Koelker · Havelsee, DE
• Ewald Rieger · Frankenthal (Pfalz), DE

Key dates

• Filing date: Sep 16, 2013
• Grant date: Sep 24, 2019
• Expiry date: Mar 10, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N27/3271
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Electrode systems are disclosed for measuring the concentration of an analyte under in vivo conditions, where the systems includes an electrode with immobilized enzyme molecules and an improved diffusion barrier that controls diffusion of the analyte from body fluid surrounding the electrode system to the enzyme molecules. Methods of making and using the system also are disclosed.