Methods for determining relative response factors for impurity analysis using liquid chromatography with absorbance and evaporative light scattering detection
US10422775B2 · kind B2 · utility
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| Filing date | Jan 12, 2017 |
| Grant date | Sep 24, 2019 |
| Priority date | — |
| Expiry date | Dec 9, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/8872
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods and systems for determining relative response factors for liquid chromatography using both molar concentration-based detection and mass concentration-based detection are described herein. A method includes determining a relative response factor for a compound based on the ratio of a molar-based peak area for the compound to the logarithm of the mass-based peak area for the compound and based on the ratio of a molar-based peak area for a reference compound divided by the logarithm of the mass-based peak area for the reference compound.
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