Method for assigning tissue normalization factors for digital image analysis
US10424061B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 2, 2017 |
| Grant date | Sep 24, 2019 |
| Priority date | — |
| Expiry date | Sep 15, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T2207/30096
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
Staining of tissue is a common approach utilized to visualize a gene product in tissue context. In certain applications, it is necessary to report a sum of events within the tissue as a specific function of the target tissue area, which is a sub-area of the total tissue, as a normalization factor for reporting the quantification. Here, we describe methods of determining target tissue area and reporting a quantification which is ratiometric to the target tissue area, utilizing computer algorithms. It is important to assign a value for the “target tissue area” in scenarios where a tissue area normalization factor is needed in the most pathologically relevant fashion during the application of tissue image analysis. We have created methods for determining and reporting “target tissue area” as normalization factor which are useful in diagnostic applications utilizing image analysis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.