Resonance Raman spectroscopy analyzer instrument for biomolecules in tissues and cells
US10426349B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Aug 22, 2016 |
| Grant date | Oct 1, 2019 |
| Priority date | — |
| Expiry date | Jul 20, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/4312
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method to detect vibrations associated with biomolecules in tissues and cellsuses Resonance Raman (RR) spectroscopy to measure specific biomolecules in tissue and cells signals. The changes of RR lines of key molecules present to the chemical conformations and change due to disease such as cancer and heart disease. Biomolecules are collagen, flavins, tryptophan, NADH, NAD, etc. The laser beams excite RR of vibration associated with absorption of the key native molecules in tissue (Tryptophan, NADH, Flavins, Collagen, carotenoids, porphyrins and others. The margin assessment and RR images in 2D and 3D regions are found by RR signals using position scanners. The intensity and the numbers of molecule fingerprints indicate the presence of and the degree of the changes of chemical conformations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.