Lipids and lipid compositions for the delivery of active agents

US10426737B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Luis Brito · Cambridge, US
• Delai Chen · Cambridge, US
• Gabriel Grant Gamber · Cambridge, US
• Andrew Geall · Littleton, US
• Kevin Love · Somerville, US
• Thomas Zabawa · Boston, US
• Frederic Zecri · Cambridge, US

Key dates

• Filing date: Dec 17, 2014
• Grant date: Oct 1, 2019
• Expiry date: Sep 3, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/00071
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides for a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R3, n, p, L1 and L2 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.