Polymeric metformin and its use as a therapeutic agent and as a delivery vehicle

US10426745B2 · kind B2 · utility

Assignee

• The University of North Carolina at Chapel Hill · US

Inventors

• Leaf Huang · Durham, US
• Yi Zhao · South Pasadena, US
• Shutao Guo · Boston, US
• Kai Shi · San Jose, US

Key dates

• Filing date: Mar 4, 2016
• Grant date: Oct 1, 2019
• Expiry date: Mar 4, 2036

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B82Y5/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are polymers comprising Metformin residues (“PolyMet”) as useful therapeutic agents, delivery vehicles and transfection agents for nucleotides. Also provided herein are methods for the treatment of a disease or an unwanted condition in a subject, wherein the methods comprise administering PolyMet as a therapeutic agent to combat the disease or condition. Also provided herein are methods for the treatment of a disease or an unwanted condition in a subject, wherein the methods comprise administering a therapeutic agent in a delivery vehicle that comprises PolyMet. Further provided herein are methods for making PolyMet.