Mitigation of epileptic seizures by combination therapy using benzodiazepines and neurosteroids

US10426786B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Michael A. Rogawski · Sacramento, US
• Isaac N. Pessah · Davis, US
• Zhengyu Cao · Woodland, US
• Pamela J. Lein · Davis, US

Key dates

• Filing date: Jul 13, 2017
• Grant date: Oct 1, 2019
• Expiry date: Jul 13, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are compositions comprising a benzodiazepine and a neurosteroid, containing one or both of the benzodiazepine and the neurosteroid in a subtherapeutic dose, and administration of such compositions for mitigation of an epileptic seizure. Further provided are compositions comprising a benzodiazepine, a neurosteroid, and an NMDA blocker, and administration of such compositions for mitigation of an epileptic seizure.