Methods and compositions of treating autoimmune diseases
US10426794B2 · kind B2 · utility
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4Claims
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Key dates
| Filing date | Apr 11, 2014 |
| Grant date | Oct 1, 2019 |
| Priority date | — |
| Expiry date | Dec 14, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y306/01005
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Embodiments of various aspects described herein are directed to methods and compositions for producing a tolerognic or immunosuppressive dendritic cell. In particular, an immunosuppressive dendritic cell can be produced by contacting a dendritic cell with an agent that stimulates the IL 27/ectonucleotidase CD39 axis signaling. In some embodiments, the methods and/or compositions described herein can be used for treating an autoimmune disease or disorder, e.g., but not limited to multiple sclerosis (MS) and type 1 diabetes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.