Compositions and methods for treating cancer with anti-CD33 immunotherapy

US10426797B2 · kind B2 · utility

Assignees

• LENTIGEN TECHNOLOGY, INC. · US
• United State of America, As Represented by the Secretary, Dept. of Health and Human Services · DK

Inventors

• Rimas J. Orentas · Seattle, US
• Dina Schneider · Potomac, US
• Boro Dropulic · Ellicott City, US
• Dimiter S. Dimitrov · Frederick, US
• Zhongyu Zhu · Frederick, US

Key dates

• Filing date: Mar 23, 2018
• Grant date: Oct 1, 2019
• Expiry date: Mar 23, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/03
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Chimeric antigen receptors containing CD33 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.