Amide compound, preparation method and uses thereof

US10428013B2 · kind B2 · utility

Assignees

• SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY · CN
• China State Institute of Pharmaceutical Industry · CN

Inventors

• Zhenpeng Yu · Shanghai, CN
• Gouping Wang · Shanghai, CN
• Zhen Zhang · Shanghai, CN
• Minyu Liu · Shanghai, CN
• Xiaoling Huang · Shanghai, CN
• Ying Liu · Hsinchu, TW
• Lin Xiao · Shanghai, CN
• Li Cai · Shanghai, CN
• Xuejun Wu · Shanghai, CN
• Yifang Deng · Shanghai, CN
• Mianli Pan · Shanghai, CN
• Renhai Chen · Shanghai, CN
• Shenrong Tang · Shanghai, CN
• Quanhai Liu · Shanghai, CN

Key dates

• Filing date: Jun 25, 2012
• Grant date: Oct 1, 2019
• Expiry date: Jan 1, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.