Tumor necrosis factor-related apoptosis-inducing ligand variant, as well as a preparation method and use thereof
US10428132B2 · kind B2 · utility
0Cited by
2References
18Claims
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Key dates
| Filing date | Feb 11, 2015 |
| Grant date | Oct 1, 2019 |
| Priority date | — |
| Expiry date | Jun 26, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/33
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses a tumor necrosis factor-related apoptosis-inducing ligand variant, which is a fusion protein of a tumor necrosis factor-related apoptosis-inducing ligand and an F3 peptide. The F3 peptide is fused to the N-terminus or C-terminus of the tumor necrosis factor-related apoptosis-inducing ligand by a linker. The present invention also discloses a nucleotide sequence, as well as a recombinant vector and a recombinant bacterium comprising same, and also discloses a preparation method and use of the foregoing variant.
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