Modulation of stimulatory and non-stimulatory myeloid cells

US10428143B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Matthew Krummel · Berkeley, US
• Miranda Broz · San Francisco, US
• Denise Wolf · San Francisco, US
• Joshua Pollack · San Francisco, US
• Mikhail Biennewies · San Francisco, US

Key dates

• Filing date: Sep 28, 2015
• Grant date: Oct 1, 2019
• Expiry date: Sep 28, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/76
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are methods and compositions for enhancing an immune response and/or for the treatment of an immune-related condition in an individual, e.g., cancer, comprising killing, disabling, or depleting non-stimulatory myeloid cells using an antigen binding protein such as an antibody or antigen binding fragment thereof.