Single-chain tumor necrosis factor (TNF) ligand family molecules, fusion proteins and derivatives thereof

US10428149B2 · kind B2 · utility

Assignee

• UNIVERSITAT STUTTGART · DE

Inventors

• Ugur Sahin · Mainz, DE
• Roland Kontermann · Jeffery Road, DE
• Klaus Pfizenmaier · Tiefenbronn, DE
• Martin Siegemund · Stuttgart, DE
• Meike HUTT · Stuttgart, DE
• Oliver SEIFERT · Stuttgart, DE

Key dates

• Filing date: Mar 18, 2016
• Grant date: Oct 1, 2019
• Expiry date: Mar 18, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/91
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention relates to a polypeptide comprising a component A with at least three tumor necrosis factor (TNF) homology domains of TNF-ligand family members (THD) in which C-terminal and N-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional C-terminal and/or N-terminal amino acids of the THD or variants thereof, and a component B comprising a dimerization domain. Further, the present invention relates to a polypeptide comprising at least three THDs in which C-terminal and N-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional C-terminal and/or N-terminal amino acids of the THD or variants thereof. Further, the invention relates to a nucleic acid comprising said polypeptides, a vector comprising said nucleic acid and a pharmaceutical composition comprising said polypeptides, or said nucleic acids or said vector. Further, the present invention relates to said polypeptides, said nucleic acid or said vector for the use as a medicament or for the use in the diagnosis, prophylaxis or treatment of hyperproliferative disorders and inflammator…