Patent · US Active

Light-emitting molecules

US10428317B2 · kind B2 · utility

0Cited by

6References

11Claims

0Family size

Assignee

GENE STREAM PTY LTD. · AU

Inventors

John Michael Daly · Perth, AU
Leon Michael Brownrigg · Melbourne, AU
Jim Yu-Hsiang Tiao · Fremantle, AU

Key dates

Filing date	Dec 5, 2011
Grant date	Oct 1, 2019
Priority date	—
Expiry date	Dec 5, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y113/12
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Luciferase polypeptides with improved light-emitting activity and their encoding nucleic acids are disclosed. These molecules are useful in a range of assays including luciferase-based gene reporter assays, bioluminescence resonance energy transfer assays, protein complementation assays and other applications in which luciferase enzymes are utilized as detectable and/or quantifiable labels. Methods and compositions for increasing the sensitivity and/or improving the kinetics of luciferase-catalyzed reactions as well as decreasing the impact of undesirable variables are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.