Stem-loop compositions and methods for inhibiting factor D
US10428330B2 · kind B2 · utility
2Cited by
31References
28Claims
0Family size
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Key dates
| Filing date | May 25, 2018 |
| Grant date | Oct 1, 2019 |
| Priority date | — |
| Expiry date | May 25, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/531
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The application discloses methods and compositions for the inhibition of the alternative complement pathway. The methods and compositions involve the use of aptamers for inhibiting complement Factor D. The application further provides anti-Factor D aptamers for the treatment of dry age-related macular degeneration, geographic atrophy, wet age-related macular degeneration or Stargardt disease. In some cases, stem-loop aptamers are provided for the inhibition of Factor D.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.