Lov-D acyltransferase mediated acylation
US10428360B2 · kind B2 · utility
1Cited by
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11Claims
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Key dates
| Filing date | Feb 2, 2018 |
| Grant date | Oct 1, 2019 |
| Priority date | — |
| Expiry date | Feb 2, 2038 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/52
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.