Patent · US Active

Tetrazine-trans-cyclooctene ligation for the rapid construction of radionuclide labeled probes

US10434197B2 · kind B2 · utility

0Cited by

1References

21Claims

0Family size

Assignees

University Of Delaware · US
University of Southern California · US

Inventors

Joseph M. Fox · Landenberg, US
Matthew Hassink · Wilmington, US
Melissa Blackman · Waltham, US
Zibo Li · Logan, US
Peter S. Conti · Pasadena, US
Ramajeyam Selvaraj · Newark, US

Key dates

Filing date	Jul 21, 2011
Grant date	Oct 8, 2019
Priority date	—
Expiry date	Aug 20, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D403/12
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A Diels-Alder adduct of a trans-cyclooctene with a tetrazine is provided, wherein the adduct bears a substituent labeled with a radionuclide. A method of producing a PET or other image of an organ in an animal or human includes forming the Diels-Alder adduct in the animal or human. Trans-cyclooctenes and tetrazines suitable for preparing the adducts are provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.