Quinoline derivatives for the treatment of inflammatory diseases

US10435370B2 · kind B2 · utility

Assignees

• ABIVAX · FR
• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• INSTITUT CURIE · FR
• Universite De Montpellier · FR

Inventors

• Jamal Tazi · Clapiers, FR
• Romain Najman · L'Haÿ-les-Roses, FR
• Florence Mahuteau · Le Puy-en-Velay, FR
• Didier Scherrer · Castelnau-le-Lez, FR
• Karim CHEBLI · Frontignan, FR
• Michael HAHNE · Montpellier, FR

Key dates

• Filing date: Jul 17, 2015
• Grant date: Oct 8, 2019
• Expiry date: Jul 17, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/178
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a compound of formula (I) wherein: Formula (II) means an aromatic ring wherein V is C or N and when V is N; Q is N or O, provided that R″ does not exist when Q is O; R′ independently represent a hydrogen atom or a group chosen among a (C1-C3)alkyl group, a halogen atom, a hydroxy! group, a —COOR1 group, a —NO2 group, a —NR1R2 group, a morpholinyl or a morpholino group, a N-methylpiperazinyl group, a (Ci-C3)fluoroalkyl group, a —O—P(═O)—(OR3XOR4) group, a (C1-C4)alkoxy group and a —CN group, and can further be a group chosen among: (IIa), (IIIa) or anyone of its pharmaceutically acceptable salt, for use in the treatment and/or prevention of an inflammatory disease.