Peptide with safer secondary structure, peptide library, and production methods for same
US10435439B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 17, 2017 |
| Grant date | Oct 8, 2019 |
| Priority date | — |
| Expiry date | Nov 7, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B40/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An object of the invention is to provide a peptide having a stabilized secondary structure.The present invention provides a peptide having a secondary structure stabilized by a crosslinked structure and containing at least one combination of a special amino acid of the formula (I): (wherein, (A) represents a single bond or a linking group having, in the main chain thereof, from 1 to 10 atoms; (B) represents a group containing at least one π bond; (C) represents a hydrogen atom or an alkyl group which may be substituted with a substituent; and X represents a group substitutable by a substitution reaction with a sulfanyl group) and an amino acid having, in the side chain thereof, a sulfanyl group; and having the crosslinked structure formed through a thioether bond between the side chain of the special amino acid residue and the sulfanyl group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.