Antibody against human prostaglandin E2 receptor EP4
US10435465B2 · kind B2 · utility
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1References
13Claims
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Assignee
Inventors
Key dates
| Filing date | Sep 24, 2015 |
| Grant date | Oct 8, 2019 |
| Priority date | — |
| Expiry date | Dec 13, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/76
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
It is an object of the present invention to provide an antibody that binds to a human PGE2 receptor subtype EP4 and inhibits the function of EP4, or a functional fragment thereof. It is another object of the present invention to provide a medicament comprising the aforementioned antibody or a functional fragment thereof. Mice were immunized with the human PGE2 receptor subtype EP4, and a monoclonal antibody that suppresses the intracellular cAMP level increase induced by EP4 was screened. In addition, the CDR sequences of the obtained monoclonal antibody were determined.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.