Micro- and nanopatterned substrates for cell migration and uses thereof
US10435734B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 9, 2016 |
| Grant date | Oct 8, 2019 |
| Priority date | — |
| Expiry date | Sep 16, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5002
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention generally relates to the field of cell growth and tissue engineering, in particular, an engineered biomimetic culture platform (BCP) that has a nanotextured and micropatterned surface that provides both chemical and mechanical cues designed to mimic the structure of the in vivo extracellular micro-environment. The BCP can be used in assays to assess the migratory behavior and/or potential of a population of cells, such as tumor cells, as well as in screening assays for diagnostic and/or prognostic purposes, or to identify agents that modify the migratory behavior or the epithelial-to-mesenchymal transition (EMT) of cells. BCPs as described herein further provide a platform for the identification of protein or genetic targets for the modification of cell migratory or invasion behavior.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.