Method to estimate age of individual based on epigenetic markers in biological sample
US10435743B2 · kind B2 · utility
1Cited by
25References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 18, 2012 |
| Grant date | Oct 8, 2019 |
| Priority date | — |
| Expiry date | Aug 8, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/154
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides methods and materials that use observation of DNA characteristics to obtain information relating to the age of individuals. The instant disclosure identifies 88 sites in or near 80 genes for which the degree of cytosine methylation in epithelial and/or white blood cells is significantly correlated with age. In illustrative embodiments of the invention, cytosine methylation patterns the promoters of the EDARADD, TOMILI, and NPTX2 genes are used to predict the age of an individual with a high degree of accuracy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.