Methods and compositions for treating osteoarthritis and promoting cartilage formation

US10441541B2 · kind B2 · utility

Assignee

• NEW YORK UNIVERSITY · US

Inventors

• Bruce N. Cronstein · New York, US
• Carmen Corciulo · Gothenburg, SE

Key dates

• Filing date: Sep 12, 2016
• Grant date: Oct 15, 2019
• Expiry date: Sep 12, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P19/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides methods and compositions for treating or inhibiting the development of osteoarthritis in a subject having osteoarthritis or at risk for developing osteoarthritis and for stimulating or increasing cartilage production or formation in a subject. The methods feature administering to the subject a therapeutically effective amount of a composition comprising one or more agent from among adenosine, an adenosine receptor agonist, and an agent that upregulates or increases the amount of or the biological activity of adenosine, or an analog or derivative thereof. The adenosine receptor may be an A1, A2A, A2B and A3 adenosine receptor. The agent that upregulates or increases the amount of or the biological activity of adenosine may be dipyridamole or ticagrelor. The composition may be administered via intraarticular injection such as injection into the synovial fluid of a joint. The composition may be effective to reduce or inhibit degeneration or damage to cartilage or to stimulate or increase cartilage production or formation. The composition may be a liposomal composition or contain a liposome.