Methods and materials for treating cancer

US10441643B2 · kind B2 · utility

Assignees

• Mayo Foundation for Medical Education and Research · US
• University of Leeds · GB

Inventors

• Jose S. Pulido · Rochester, US
• Richard G. Vile · Rochester, US
• Timothy J. Kottke · Oronoco, US
• Jill M. Thompson · Stewartville, US
• Rosa Maria Diaz · Rochester, US
• Christine Marie Pulido · Rochester, US
• Alan A. Melcher · Leeds, GB
• Peter Selby · Leeds, GB

Key dates

• Filing date: Mar 19, 2015
• Grant date: Oct 15, 2019
• Expiry date: Mar 19, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/20243
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This document provides methods and materials for treating cancer. For example, methods and materials for treating cancer using combinations of antigens are provided. For example, VSV vectors designed to express a GNAQ antigen, a TYRP1 antigen, and an N-RAS antigen can be used to reduce the number of cancer cells (e.g., uveal melanoma cells) within a mammal (e.g., a human). In some cases, VSV vectors designed to express a BRAF antigen, a TOPO-11a antigen, and a YB-I antigen can be used to reduce the number of cancer cells (e.g., skin melanoma cells) within a mammal (e.g., a human). The composition can comprise less than 50 separate nucleic acid molecules.