Synthesis of tyrosine derived diphenol monomers
US10442757B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 7, 2018 |
| Grant date | Oct 15, 2019 |
| Priority date | — |
| Expiry date | May 7, 2038 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D11/0492
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A method for preparing diphenol compounds includes adding a hydroxyphenyl carboxylic acid, a tyrosine ethyl ester, hydroxybenzotriazole hydrate and a solvent and stirring to produce a first solution. EDCI HCl is added to the first solution to produce a first mixture. Ethyl acetate is added to the first mixture to produce a second mixture. The second mixture is added to sodium chloride to produce a third mixture having layer separation. An aqueous layer is removed from the third mixture. The third mixture is extracted with reagents after the aqueous layer has been removed from the third mixture to produce a fourth mixture. Magnesium sulfate is added to the fourth mixture to produce a fifth mixture. The fifth mixture is filtered to produce filtrate. The filtrate is concentrated. Crystallization of the concentrated filtrate is induced. Methylene chloride is added to the crystallized filtrate to produce a solid product.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.