1-sulfonamido-4-aryloxy compounds, and preparation method and medicinal application thereof

US10442759B2 · kind B2 · utility

Assignee

• CHINA PHARMACEUTICAL UNIVERSITY · CN

Inventors

• Qidong You · 安丰镇, CN
• Zhengyu JIANG · Nanjing, CN
• Mengchen Lu · Nanjing, CN
• Zhiyun Chen · Longbeilingcun, CN
• Haopeng Sun · 安丰镇, CN
• Xiaojin ZHANG · Nanjing, CN
• Xiaoke GUO · 安丰镇, CN
• Xiaoli Xu · Shanghai, CN

Key dates

• Filing date: Nov 25, 2016
• Grant date: Oct 15, 2019
• Expiry date: Nov 25, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D257/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula (I) having 1-sulfonamido-4-aryloxy as a basic backbone. A preliminary activity test showed that the compounds provide excellent interference of a binding of Nrf2 by Keap1, thereby activating Nrf2. The compounds have a potential anti-inflammatory activity and can be used to treat a plurality of inflammation-associated diseases, including chronic obstructive pulmonary disease (COPD), Alzheimer's disease, Parkinson's disease, atherosclerosis, chronic kidney disease (CKD), diabetes, gastroenteritis, rheumatoid arthritis, and the like.