Method for producing 2-aminonicotinic acid benzyl ester derivative
US10442768B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 8, 2016 |
| Grant date | Oct 15, 2019 |
| Priority date | — |
| Expiry date | Nov 8, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B61/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a method for producing a 2-aminonicotinic acid benzyl ester derivative. The method includes, as a step, reacting a 2-aminonicotinic acid derivative represented by the formula [I], wherein R1 represents a hydrogen atom or a C1 to C4 alkyl group and M represents an alkali metal, with a benzyl derivative represented by the formula [II], wherein R2 represents, for example, a hydrogen atom or a halogen atom, A represents, for example, a nitrogen atom, X represents a halogen atom, and Y represents, for example, an oxygen atom, in an aromatic hydrocarbon solvent in the presence of a phase transfer catalyst or a tertiary amine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.