Patent · US Active

Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use

US10442789B2 · kind B2 · utility

2Cited by
3References
11Claims
0Family size

Assignee

Inventors

Key dates

Filing dateDec 6, 2017
Grant dateOct 15, 2019
Priority date—
Expiry dateDec 6, 2037

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12Y601/01001
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Provided herein are modified amino acids comprising a tetrazine groups according to Formula I: polypeptides, antibodies, payloads and conjugates comprising these modified amino acid residues derived from the modified amino acids, and methods of producing the polypeptides, antibodies, payloads and conjugates comprising the modified amino acid residues. The polypeptides, antibodies, payloads and conjugates are useful in methods of treatment and prevention, methods of detection and methods of diagnosis.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.