Cleavage resistant photoluminescent proteins and applications thereof

US10442842B2 · kind B2 · utility

Assignee

• THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS · US

Inventors

• Robert Beitle · Fayetteville, US
• Rudra Palash Mukherjee · Fayetteville, US
• Suresh Kumar Thallapuranam · Fayetteville, US
• Joshua Sakon · Fayetteville, US
• David S. McNabb · Fayetteville, US

Key dates

• Filing date: Mar 2, 2017
• Grant date: Oct 15, 2019
• Expiry date: Aug 18, 2037

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01D15/08
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

Photoluminescent proteins resistant to protein cleavage reagents are described herein. In being resistant to cleavage reagents, such photoluminesncent proteins can reduce the number of digestion or cleavage products, thereby simplifying quantification and purification of recombinant protein compositions. In some embodiments, a photoluminescent protein described herein comprises an amino acid sequence having an absence of internal methionine residues.