Polygonal scaffold and manufacturing method thereof, and protein modulator and manufacturing method thereof
US10443026B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 25, 2017 |
| Grant date | Oct 15, 2019 |
| Priority date | — |
| Expiry date | Dec 25, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/30
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A polygonal scaffold includes at least three polyproline II (PPII) helix rods and at least three connectors. Each of the PPII helix rods is composed of a plurality of repeat units represented by Formula (i), and at least one of the PPII helix rods has at least one hydrogen atom of at least one of the repeat units being substituted by a first chemical handle for connecting a ligand. Each of the connectors is a divalent organic group, and every two of the PPII helix rods are connected by one of the connectors to form a closed ring. Therefore, with the uniform composition, the PPII helix rods have a stable helical structure under aqueous conditions, and a desired rigidity can be provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.