Generating cardiac progenitor cells from pluripotent stem cells using isoxazole or isoxazole like compounds
US10443044B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Jul 1, 2016 |
| Grant date | Oct 15, 2019 |
| Priority date | — |
| Expiry date | May 27, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2506/45
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This disclosure provides a chemically modified induced pluripotent stem (iPS) cell derived from parental cells and methods for generating the chemically induced pluripotent stem (iPS) cells, as well as cardiac progenitor cells capable of producing cells of multiple sub-lineages. The iPS cells are useful in method for or regenerating cardiac muscle tissue or to promote the replacement of cardiac scar tissue or to rejuvenating cardiac muscles in a patient in need thereof and to treat cardiac disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.