Multi-targets interfering RNA molecules and their applications

US10443057B2 · kind B2 · utility

Assignee

• Biomics Biotechnologies, Co., Ltd. · CN

Inventors

• York Yuan Yuan Zhu · Palo Alto, US
• Tiejun Li · Beijing, CN

Key dates

• Filing date: Jul 22, 2015
• Grant date: Oct 15, 2019
• Expiry date: Aug 20, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/531
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to interfering RNA (iRNA) molecules and their applications, especially multi-targets iRNA molecules and their applications. The said multi-targets iRNA molecules comprised of a sense strand annealed onto at least one antisense strand, each strand is at least 30 nucleotides in length, the sense or antisense strand has at least two segments, which can target at least two RNAs of different genes, or can target at least two portions of an RNA, and wherein the iRNA does not induce an interferon-response when transfected into a cell. The iRNA molecule can interfere with the translation procedure post-transcription, and the target gene is inhibited or blocked, the iRNA does not induce an interferon-response in vivo. The RNA molecules are the active ingredient in preparation of the drug which can regulate one or many genes function.