Selective capture and stimulated release of circulating tumor cells on nanostructured devices
US10444233B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 31, 2013 |
| Grant date | Oct 15, 2019 |
| Priority date | — |
| Expiry date | Dec 27, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/70596
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A device for capturing preselected cell types from a fluid sample that includes a plurality of cell types includes a substrate, a plurality of nanowires at least one of attached to or integral with a surface of the substrate such that each nanowire of the plurality of nanowires has an unattached end, and a layer of temperature-responsive material formed on at least the unattached end of each of the plurality of nanowires. The layer of temperature-responsive material has a compact configuration at a first temperature and an expanded configuration at a second temperature so as to facilitate release of cells captured at the first temperature to be released at the second temperature.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.