Composition with high antimicrobial activity and low toxicity

US10448634B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• AMICROBE, INC. · US

Inventors

• Michael P. Bevilacqua · Holbrook, US
• Diego Benitez · Calabasas, US
• Timothy J. Deming · Summerland, US
• Jarrod A. Hanson · Los Angeles, US
• Lucas Koziol · Penngrove, US

Key dates

• Filing date: Apr 22, 2015
• Grant date: Oct 22, 2019
• Expiry date: Sep 24, 2036

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Improved synthetic copolypeptide antimicrobials contain cationic amino acid residues and may be based on a blocky sequence. These antimicrobials show low mammalian toxicity and may undergo directed self-assembly. The inventive synthetic copolypeptides are useful in treatment of wounds and other infections.