High-frequency electroporation for cancer therapy
US10448989B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 20, 2011 |
| Grant date | Oct 22, 2019 |
| Priority date | — |
| Expiry date | May 14, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B2018/126
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.