Immunostimulating oligonucleotide complex
US10449212B2 · kind B2 · utility
3Cited by
2References
15Claims
0Family size
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Key dates
| Filing date | Jul 8, 2016 |
| Grant date | Oct 22, 2019 |
| Priority date | — |
| Expiry date | Jul 8, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/117
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is an immunostimulating oligonucleotide that is suitable for industrial production and has an excellent type-I IFN inducing activity even when not modified to become a phosphorothioate. This linear double-stranded oligonucleotide contains 10-100 base pairs, wherein the single-stranded oligonucleotides constituting the double-stranded oligonucleotide each contain 2-20 phosphodiester-mediated cytosine-guanine (CpG) sequences, and at least 90% of the internucleotide bonds in each single-stranded oligonucleotide are phosphodiester bonds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.