Gas delivery devices

US10449321B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Mark E. Meyerhoff · Ann Arbor, US
• Nicolai Lehnert · Ann Arbor, US
• Yu Qin · Ann Arbor, US
• Andrew P. Hunt · Ann Arbor, US
• Elizabeth J. Brisbois · Athens, US
• Hang Ren · Beijing, CN

Key dates

• Filing date: Apr 11, 2017
• Grant date: Oct 22, 2019
• Expiry date: Feb 15, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61M2202/0275
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A gas delivery device includes a nitric oxide generating system. The system has a medium including a source of nitrite ions. A working electrode is in contact with the medium. A Cu(II)-ligand complex is in contact with the working electrode. A reference/counter electrode is, or a reference electrode and a counter electrode are in contact with the medium and separated from the working electrode. An inlet conduit is to deliver nitrogen gas to the medium, and an outlet conduit is to transport a stream of nitrogen gas and nitric oxide from the medium. An inspiratory gas conduit is operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.