Devices and methods for modulation of bone erosion
US10449358B2 · kind B2 · utility
17Cited by
280References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 4, 2017 |
| Grant date | Oct 22, 2019 |
| Priority date | — |
| Expiry date | Apr 17, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N1/36175
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Devices and methods for stimulation of the vagus nerve to modulate (e.g., reduce, suppress, etc.) bone erosion. Methods and apparatus for modulating bone erosion may modulate levels of Receptor Activator for Nuclear Factor κB Ligand (RANKL), and/or to modulate (increase, enhance, etc.) osteoprotegerin (OPG) and/or OPG/RANKL ratio. Devices may include electrical stimulation devices that may be implanted, and may be activated to apply current for a proscribed duration, followed by a period without stimulation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.