Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B

US10450270B2 · kind B2 · utility

Assignee

• Janssen Sciences Ireland UC · IE

Inventors

• Koen Vandyck · Beringen, BE
• Bart Rudolf Romanie Kesteleyn · Berlare, BE
• Serge Maria Aloysius Pieters · Wichelen, BE
• Geert Rombouts · Borsbeek, BE
• Wim Gaston Verschueren · Berchem, BE
• Pierre Jean-Marie Bernard Raboisson · Sligo, IE

Key dates

• Filing date: Jul 25, 2014
• Grant date: Oct 22, 2019
• Expiry date: Jul 25, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Inhibitors of HBV replication of Formula (IA) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X and R1 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.