Bifunctional molecules for degradation of EGFR and methods of use
US10450310B2 · kind B2 · utility
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4References
18Claims
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Key dates
| Filing date | Oct 17, 2018 |
| Grant date | Oct 22, 2019 |
| Priority date | — |
| Expiry date | Oct 17, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present application provides bifunctional compounds of Formula (I): which act as protein degradation inducing moieties for EGFR and/or a mutant thereof. The present application also describes methods for the targeted degradation of EGFR and/or a mutant thereof through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to EGFR and/or a mutant thereof which can be utilized in the treatment of disorders modulated by EGFR or a mutant thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.