Nitrogen-rich macrocyclic ligands, chelation complexes thereof, and process for selective chelation of radioactive bismuth ions with the ligands

US10450336B2 · kind B2 · utility

Assignee

• Triad National Security, LLC · US

Inventors

• Justin Wilson · Cambridge, US
• Eva R. Birnbaum · Los Alamos, US
• Kevin John · Santa Fe, US
• Francois Meiring Nortier · Los Alamos, US
• Michael E. Fassbender · Los Alamos, US
• Valery Radchenko · Los Alamos, US
• Jonathan W. Engle · Los Alamos, US

Key dates

• Filing date: May 4, 2015
• Grant date: Oct 22, 2019
• Expiry date: Jan 17, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Selective chelation of bismuth radionuclide ions from a mixture including actinium radionuclide ions involves exposing a ligand to an aqueous solution that includes bismuth radionuclide ions and actinium radionuclide ions under conditions whereby the bismuth radionuclide ions selectively chelate to the ligand for form cationic complexes of the bismuth radionuclide ions. and separating the cationic complexes of the bismuth radionuclide ions from the actinium radionuclide ions. The ligands have a structure based on a 12-membered cyclen ring and may include pendant functional groups that can be derivatized with biological targeting vectors for targeted alpha therapy.