Charged nutritive proteins and methods

US10450350B2 · kind B2 · utility

Assignee

• AXCELLA HEALTH INC. · US

Inventors

• David Arthur Berry · Brookline, US
• Brett Adam Boghigian · Boston, US
• Nathaniel W. Silver · Cambridge, US
• Geoffrey von Maltzahn · Boston, US
• Michael Hamill · Wellesley, US
• Rajeev Chillakuru · Cambridge, US
• John F. Kramarczyk · Somerville, US

Key dates

• Filing date: Feb 10, 2017
• Grant date: Oct 22, 2019
• Expiry date: Feb 10, 2037

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Charged nutritive proteins are provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 50 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 100 g/L at pH 7. In some embodiments the nutritive proteins comprise at least one of a level of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of branch chain amino acid residues to total amino acid residues present in a benchmark protein; b) a ratio of leucine residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of leucine residues to total amino acid residues present in a benchmark protein; and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of essential amino acid residues to total amino acid residues present in a benchmark protein. Also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, met…