Methods related to CTLA4-Fc fusion proteins

US10450361B2 · kind B2 · utility

Assignee

• MOMENTA PHARMACEUTICALS, INC. · US

Inventors

• John Robblee · Newton, US
• Xiaomei He · Cambridge, US
• Yan Yin · Cambridge, US
• Yin Yin Lin · Cambridge, US
• Brian Edward Collins · Arlington, US
• Jennifer Murphy · Cambridge, US
• Ganesh Kaundinya · Bedford, US

Key dates

• Filing date: May 31, 2013
• Grant date: Oct 22, 2019
• Expiry date: Nov 10, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/30
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present disclosure provides, in part, methods for evaluating, identifying, and/or producing (e.g., manufacturing) a CTLA4-Fc fusion protein, e.g., abatacept. In some instances, methods herein allow highly resolved evaluation of abatacept useful for, inter alia, manufacturing abatacept, characterizing abatacept, identifying and/or confirming abatacept, monitoring the structure of abatacept, comparing abatacept preparations made over time or made under different conditions, and/or controlling the structure of abatacept.