Method for detecting a solid tumor cancer
US10451626B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Mar 11, 2015 |
| Grant date | Oct 22, 2019 |
| Priority date | — |
| Expiry date | Jul 30, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/96455
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for indicating a presence or non-presence of a predefined solid tumor cancer in an individual, comprising the steps of: A. Providing at least one biological sample originating from said individual at a first point in time; B. Providing at least one biological sample originating from said individual at a second point in time; C. In said at least two biological samples, measuring a presence or concentration of at least one biomarker related to said predefined solid tumor cancer; D. Combining data regarding the presence or concentration of the at least one biomarker to form a kinetic composite value that reflects the change of biomarker presence or concentration; E. Correlating the kinetic composite value to the presence or non-presence of said predefined solid tumor cancer in said individual by comparing the kinetic composite value to a pre-determined cut-off value established with control samples of known predefined solid tumor cancer and benign disease diagnosis; wherein the time period between the first point in time and the second point in time is in the range from 0.5% to 25%, or more preferably in the range from 0.1% to 15%, of a typical tumor volume doubling time of s…
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